Cannabis: The Ultimate Guide


Biotics Research Article


What is all the fuss about cannabinoids? Is it all about cannabis or is there more to the hype? These are common questions, and for good reason. Although cannabinoids were pinpointed thanks to research into cannabis, cannabinoids are proving to be a treasure trove for deep exploration into holistic health and well-being.


In this ultimate guide to cannabinoids - we’ll explore cannabinoids from all angles, including the entourage effect, cannabinoids in breast milk, natural ways to boost cannabinoids, the bliss molecule, labelling accuracy and the ins and outs of the endocannabinoid system, and much more.


What are cannabinoids?

Cannabinoids are any chemical substances that bind to the cannabinoid receptors in the central nervous system (CNS) and have been used extensively throughout the world for their medicinal and recreational effects. We now know that there are naturally occurring cannabinoids in the human body called endocannabinoids.


How do you pronounce cannabinoids?

“Cannabinoid” is pronounced [kuh-nab-uh-noid, kan-uh-buh-] and phytocannabinoids is pronounced [Fight-o cuh-nabba-uh-noids] .


How do cannabinoids work in the human body?

Despite records of the medicinal use of marijuana dating back 4700 years, we didn’t understand how it worked in the human body until 1964 when Yechiel Gaoni and Raphael Mechoulam isolated the main psychoactive component of cannabis - tetrahydrocannabinol (THC). Thanks to these researchers discovering the first cannabinoid, THC, the door was thrown open for further study into how cannabinoids work in the human body.


What are cannabinoid receptors?

Cannabinoid receptors are found throughout the body and are part of the endocannabinoid system. Cell membranes of the receptors respond to cannabinoids, sending nerve signals to alter various processes in the body. The main cannabinoid receptors are known as CB1 and CB2. Endocannabinoids are naturally-occurring substances produced by the brain that bind with CB1. An example of an endocannabinoid is anandamide (N-arachidonylethanolamine).


CB1 and its splice variant CB1A are densely located in the cerebellum, hippocampus, neocortex, amygdala, and striatum. As such, a wide range of behavioral functions related to emotion, memory, sensory perception, hunger, and motor responsiveness is mediated by CB1 receptors. CB1 is the predominant cannabinoid receptor in the CNS. CB2, on the other hand, is found outside the CNS - in the spleen and hematopoietic cells - making CB2 a modulator of the immune system.


What are cannabinoids responsible for?

The most common form of cannabinoids “CB1” are located in the brain and are responsible for just about every reaction in the body. From the immune system, decision-making and behavior to the dampening of excitatory transmission, the endocannabinoid system is ubiquitous throughout the human organism. It is also closely linked with brain function.